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Mia Sara
Mia SaraMia Sara will play the character of Dr. Harleen Quinzel (aka. Harley Quinn).

The following is from Comics Continuum:

Sara replaces Sherilyn Fenn, who played the role in the Birds of Prey pilot, but could not commit to a regular role in the series. Fenn's scenes will be re-shot for the series.

Sara, 35, is probably best known as Ferris Bueller's girlfriend Sloane in Ferris Bueller's Day Off from 1986. She also starred in the 1994 film Timecop, based on the Dark Horse comic book, and her film and television credits number more than 30.

Sara is married to Jason Connery, the son of Sean Connery, who has played Dominic in Smallville.

From the WB website:

Born June 19

Mia Sara stars in The WB's new action-drama series, Birds of Prey as Dr. Harleen Quinzel, a brilliant madwoman who uses her day job as a therapist to achieve her savage purpose to take control of the city of New Gotham.

Born and raised in Brooklyn, N.Y., Sara realized her dream to become an actress when she was still a teenager. She fell in love with old Hollywood stars such as Bette Davis, Katherine Hepburn and Marlene Dietrich. Intrigued by the double bills at the Regency Theatre in Uptown Manhattan, she knew acting was her calling when she went to a movie theater with her mother to see The French Lieutenant's Woman and walked out of the theater in full character.

In 1985, Sara made her film debut in Ridley Scott's dark fantasy feature film Legend as Princess Lily opposite Tom Cruise and Tim Curry. Sara is most recognized from her role as Sloane Peterson, the girlfriend of Matthew Broderick's character in the high school comedy, Ferris Bueller's Day Off. Sara's past film credits include A Stranger Among Us with Melanie Griffith and Time Cop with Jean Claude Van Damme.

Sara's television credits include the life story of Queenie Kelly from India to England in the television mini-series Queenie with Kirk Douglas, 20,000 Leagues Under the Sea co-starring with Michael Caine and Patrick Dempsey and Brian Henson's (son of Jim Henson) Jack and the Beanstalk: The Real Story with Matthew Modine and Vanessa Redgrave.

Sara currently resides in Los Angeles with her 5-year-old son. When not working, she enjoys reading, practicing yoga and spending time with her son.